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. 2023 Jan 5;14:77. doi: 10.1038/s41467-022-35727-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Boxplots showing proportion of SNVs per tumor (colored circles), which are clonal. Wilcoxon 2-tailed p-value shown. Colors indicate tumor type. Boxplots show quartiles with whiskers representing 1.5x interquartile range. N = 47 biologically independent samples from distinct patients. X-axis depicts TP53 status, Y-axis depicts proportion of SNVs which are clonal. B Boxplots showing proportion of CNVs per tumor (colored circles), which are clonal. Wilcoxon 2-tailed p-value shown. Boxplots show quartiles with whiskers representing 1.5x interquartile range. Colors indicate tumor type. -axis depicts TP53 status, Y-axis depicts proportion of CNVs which are clonal. C, D Phylogenetic reconstructions of LFS tumors using multiregion WGS (C) Circle plots, with subclonal cluster number on X-axis and tumor region on Y-axis. Circles are colored by tumor region. Circle diameter corresponds to cancer cell fraction (CCF) for each cluster for each tumor region. D Phylogenetic tree reconstructions of each multiregion sequenced tumor with colors corresponding to tumor region, numbers corresponding to cluster number and annotated with location of driver mutations. Source data are provided as a Source Data file.