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. 2023 Jan 5;14(1):6. doi: 10.1038/s41419-022-05524-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a In transient transfection experiment with HCT116 and SW480 cells, compared with a mock control plasmid, the levels of TRAF6 protein in colorectal cancer cells in the TRAF6 overexpression group was significantly changed. b Overexpression of TRAF6 cell state in HCT116 and SW480 cells was significantly changed under light microscopy (×200). c In HCT116 and SW480 cells, transient transfection of knockdown TRAF6 group colorectal cancer cells showed significant alterations in TRAF6 protein expression levels. d In HCT116 and SW480 cells, the cellular state of knockdown TRAF6 was altered under light microscopy (×200). e Ultrastructural differences of colorectal cancer cells observe electron microscope (×2000) with differentially-expressed TRAF6 protein. f, g Detecting the TRAF6 mRNA and protein levels in ten clinical tissue samples, they were sorted into the TRAF6 Low and TRAF6 High groups by the median number of TRAF6 protein levels. Random matching was performed to obtain the mRNA (f) and protein-level (g) results. h Serial immunohistochemical sections of tissue specimens from colorectal cancer patients with differential TRAF6 protein levels, images were obtained with an inverted microscope (×400). (*p < 0.05, **p < 0.01, ***p < 0.001, with an unpaired Student’s t test (a, b, f) or one-way ANOVA analysis (c, d)).