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. 2023 Jan 5;14(1):6. doi: 10.1038/s41419-022-05524-y

Fig. 7. TRAF6 promotes colorectal cancer cell proliferation by inhibiting necroptosis through TRAF-C and RING/ZnF domains.

Fig. 7

a–e SW480 cells were co-transfected with Flag-TRAF-C or Flag-RING/ZnF plasmids, and the protein levels of TRAF6, RIPK1, RIPK3, and MLKL were obtained in western blotting (a), and images were obtained in light microscopy (b). Necroptosis of the transfected cells was analyzed (c), as well as cell proliferation (d) and clonal colony formation (e). (*p < 0.05, **p < 0.01, ***p < 0.001, with one-way ANOVA analysis (c–e)).