Table 2.

Results of general analysis on normative cutoffs

Normative cutoffs	Patients (n = 45)		Healthy controls (n = 25)		PPV	NPV	FPR	FNR	ACC
	T + /T–	Sensitivity (95% CI)	T + /T–	Specificity (95% CI)
Nasreddine et al. (2005)
< 26	42/3	0.93 (0.84–0.98)	14/11	0.44 (0.32–0.56)	0.75	0.79	0.56	0.07	0.75
Conti et al. (2015)
ES0 uL ≤ 17.36	9/36	0.20 (0.12–0.32)	0/25	1.00 (0.93–1.00)	1.00	0.41	0.00	0.80	0.48
ES1 uL < 19.50	23/22	0.51 (0.39–0.63)	2/23	0.92 (0.82–0.97)	0.92	0.51	0.08	0.49	0.66
ES2 uL < 21.56	31/14	0.69 (0.57–0.79)	5/20	0.80 (0.68–0.88)	0.86	0.59	0.20	0.31	0.73
ES3 uL < 23.36	40/5	0.89 (0.79–0.95)	13/12	0.48 (0.36–0.60)	0.75	0.71	0.52	0.11	0.74
Santangelo et al. (2015)
ES0 uL ≤ 15.50	4/41	0.09 (0.04–0.19)	0/25	1.00 (0.93–1.00)	1.00	0.38	0.00	0.91	0.41
ES1 uL < 18.28	10/35	0.22 (0.13–0.34)	0/25	1.00 (0.93–1.00)	1.00	0.42	0.00	0.78	0.50
ES2 uL < 20.25	17/28	0.38 (0.27–0.50)	1/24	0.96 (0.88–0.99)	0.94	0.46	0.04	0.62	0.58
ES3 uL < 22.23	25/20	0.56 (0.43–0.67)	1/24	0.96 (0.88–0.99)	0.96	0.54	0.04	0.44	0.70
Aiello et al. (2022)
ES0 uL ≤ 18.58	11/34	0.24 (0.15–0.36)	1/24	0.96 (0.88–0.99)	0.92	0.41	0.04	0.75	0.50
ES1 uL < 20.69	22/23	0.49 (0.37–0.61)	1/24	0.96 (0.88–0.99)	0.96	0.51	0.04	0.51	0.66
ES2 uL < 22.56	33/12	0.73 (0.61–0.83)	7/18	0.72 (0.60–0.82)	0.82	0.60	0.28	0.27	0.73
ES3 uL < 24.52	39/6	0.87 (0.76–0.93)	10/15	0.60 (0.48–0.71)	0.80	0.71	0.40	0.13	0.77

ES equivalent score, uL upper limit, T + positive test result, T– negative test result, PPV positive predictive value, NPV negative predictive value, FPR false positive rate, FNR false negative rate, ACC accuracy