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. 2022 Dec 23;13:1068855. doi: 10.3389/fphar.2022.1068855

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Copyright © 2022 Zhang, Liu, Liu and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Wogonin inhibitd pancreatic cancer in vivo by inhibiting Akt pathway (A)Orthotopic pancreatic cancer mouse model experimental design (B) Body weight changes of mice in Con group, Gem group and Gem + Wog group within 21 days (C) Tumor size (D) Tumor weight (E) The fixed sections of mouse pancreas and pancreatic cancer were stained with Ki67 to detect tumor proliferation (F) After cryopreservation of mouse pancreatic tumors, Western Blot was detected to compare the expression of p-AKT, AKT, BAD and bcl-2 proteins in Con group, Gem group and Gem + Wog group. *p < 0.05, **p < 0.01, * **p < 0.001 vs. controls.