FIGURE 3.

Actual values of 6-min walk distance (6MWD). Data are from the extension period full analysis set. Minimum, lower quartile, median, upper quartile and maximum values are displayed. Outliers were identified and removed from the plots. Threshold values for multiple endpoints have been proposed in the 2015 European Society of Cardiology/European Respiratory Society guidelines to determine prognosis of patients with pulmonary arterial hypertension. According to these guidelines, a threshold value of 6MWD >440 m is considered low risk; 6MWD 165–440 m is considered intermediate risk; and 6MWD <165 m is considered high risk. EOP: end of placebo-controlled treatment period.