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. 2023 Jan 5;61(1):2201347. doi: 10.1183/13993003.01347-2022

FIGURE 5.

FIGURE 5

World Health Organization functional class (WHO FC) by visit. Threshold values for multiple endpoints have been proposed in the 2015 European Society of Cardiology/European Respiratory Society guidelines to determine prognosis of patients with pulmonary arterial hypertension. According to these guidelines, WHO FC I/II is considered low risk; WHO FC III is considered intermediate risk; WHO FC IV is considered high risk. #: WHO FC data at months 18–24 were missing for six (6.2%) participants; two due to COVID-19 and four due to unknown reasons. EOP: end of placebo-controlled treatment period.