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. 2023 Jan 5;13(1):e1158. doi: 10.1002/ctm2.1158

FIGURE 8.

FIGURE 8

CircZSWIM6 aggravates osteoarthritis (OA) progression in a murine model: (A) a chart for OA model construction, CircZSWIM6 AAV injection and evaluation; (B) representative images of and Safranin‐O/Fast green staining of cartilage in sham, DMM and DMM + AAV CircZSWIM6 groups; (C) Osteoarthritis Research Society International (OARSI) grade system used for cartilage degradation evaluation in the three groups (n = 6); (D) micro‐CT 3D images and osteophytes in knee joints (n = 6); (E) H&E staining of synovium (n = 6); (F–H) quantification of synovium thickness, osteophytes number and cartilage thickness (n = 6); (I) representative immunofluorescence images of ribosomal protein S14 (RPS14), p‐AMPK and phoenolpyruvate carboxykinase 1 (PCK1) of articular cartilage in the three groups; (J) Graphical abstract of mechanism of CircZSWIM6 in OA and cellular senescence development; quantitative data shown as mean ± SD; exact p‐values are shown in figures. Two‐side unpaired Student's t‐test was used for statistical analysis. One‐way ANOVA with Tukey's multiple comparison was used for statistical analysis.