Fig. 4.

Successful use of a multitargeted tyrosine kinase inhibitor cabozantinib in a patient with advanced clear cell renal cell cancer. Patient is a 51-year-old male with progressive clear cell renal cell carcinoma. Per discussion with medical oncology team, the consensus was for systemic treatment and restaging, as patient was not a candidate for surgery. Sagittal and axial magnetic resonance imaging of thoracic and lumbar spine prior to initiation of treatment showing significant compression of the thecal sac (A,B) and 3 months after treatment with cabozantinib (C, D) showing resolution of the lesion and significant improvement in cord compression and disease burden.