Fig. 5.

Successful use of multitargeted tyrosine kinase inhibitor Lenvatinib in a patient with recurrent follicular thyroid carcinoma. Patient is a 70-year-old female who had undergone prior corpectomy with cage placement and posterior spinal fusion, followed by treatment with iodine, external beam radiation therapy and spine stereotactic radiosurgery, with significant progression of her disease shortly thereafter. Sagittal and axial magnetic resonance imaging of cervical and thoracic spine prior to initiation of treatment showing significant anterior cord compression C4–7 (A, B) and 3 months after treatment with Lenvatinib (C, D), showing resolution of the lesion and significant improvement in cord compression.