TABLE 1:

Comparison of the effects of different mutations of perturbations on multiple aspects of morphogenesis.

	cno null(Sawyer et al. 2009; 2011; Manning et al., 2019)	Rap1 RNAi (This work)	cno∆RA (Perez-Vale et al. 2021)	dzy RNAi(This work)
Overall morphogenesis as assessed by cuticles	Head involution and dorsal closure failure Moderate-Strong defects in overall epidermal integrity	Head involution and dorsal closure failureModerate-Strong defects in overall epidermal integrity	Complete failure of both head involution and dorsal closure	Failure of head involution. Dorsally closed but frequent dorsal or ventral holes
Cell shape defects and gaps at AJs under tension	Gaps common (20–30 gaps/field of view) but with only modest and late hyperconstriction	Widespread unbalanced apical constriction and epithelial infolding; gaps present in less affected areas	Gaps common (20–30 gaps/field of view) but with only modest and late hyperconstriction	Gaps common (20–30 gaps/field of view) but with only modest and late hyperconstriction
Planar cell polarity
Baz	Planar polarity enhanced	AJ localization strongly disrupted	Planar polarity enhanced	Planar polarity enhanced
Cno	NA	Planar polarity enhanced and more punctate	Planar polarity enhanced	Planar polarity unaffected
Arm	Planar polarity enhanced	Planar polarity enhanced and more punctate	Planar polarity enhanced	Planar polarity unaffected
AJ integrity	Frequent large holes in the ventral epidermis	Only dorsal epidermis remains intact	Small holes in the ventral epidermis	Small holes in the ventral epidermis