. 2022 Oct 26;42(1):20–30. doi: 10.14366/usg.22103

Table 1.

Characteristics of the studies, including country, contrast mode and agent, diagnostic standard, and final diagnosis method

Study	Country	Study type	Contrast mode	Contrast agent	Diagnostic standard	Final diagnosis
Saftoiu et al. (2010) [27]	Romania	Prospective	Power Doppler	Sonovue	Elastography: mean hue histogram >175	Histology
Saftoiu et al. (2010) [27]	Romania	Prospective	Power Doppler	Sonovue	CE-EUS: hypovascularity	6-Month follow-up
Hocke et al. (2012) [24]	Germany	Prospective	Color/power Doppler	Sonovue	Elastography: hue color map (blue coding)	Histology
Hocke et al. (2012) [24]	Germany	Prospective	Color/power Doppler	Sonovue	CE-EUS: hypoenhancement	6-Month follow-up
Iordache et al. (2016) [25]	Romania	Retrospective	Power Doppler	Sonovue	Elastography: mean hue histogram >175	Histology
Iordache et al. (2016) [25]	Romania	Retrospective	Power Doppler	Sonovue	CE-EUS: hypoenhancement	1-Year follow-up
Iglesias-Garcia et al. (2017) [26]	Spain	Prospective	Power Doppler	Sonovue	Elastography: mean hue histogram >50 and strain ratio >10	Histology
Iglesias-Garcia et al. (2017) [26]	Spain	Prospective	Power Doppler	Sonovue	CE-EUS: hypovascularity	2-Year follow-up
Chantarojanasiri et al. (2017) [22]	Japan	Retrospective	Color Doppler	Sonazoid	Elastography: hue color map (blue coding)	Histology
Chantarojanasiri et al. (2017) [22]	Japan	Retrospective	Color Doppler	Sonazoid	CE-EUS: hypovascularity	6-Month follow-up
Costache et al. (2020) [23]	Germany, Italy, France, Spain, China, and Romania	Prospective	Power Doppler	Sonovue	Elastography: mean strain histogram <80	Histology
Costache et al. (2020) [23]	Germany, Italy, France, Spain, China, and Romania	Prospective	Power Doppler	Sonovue	CE-EUS: hypoenhancement	6-Month follow-up

CE-EUS, contrast-enhanced endoscopic ultrasonography.