Table 3.
Top dysregulated pathways in pristane-exposed lupus mice.
| MMU pathway ID | Term Description | Strength | False Discovery Rate | Source |
|---|---|---|---|---|
| 2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 | 1.51 | 1.80E-03 | Reactome |
| 69478 | G2/M DNA replication checkpoint | 1.38 | 2.28E-02 | Reactome |
| 6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | 1.31 | 1.00E-03 | Reactome |
| 380108 | Chemokine receptors bind chemokines | 1.09 | 1.91E-09 | Reactome |
| 75205 | Dissolution of Fibrin Clot | 1.09 | 2.02E-02 | Reactome |
| WP460 | Blood clotting cascade | 1.08 | 6.50E-04 | Wiki |
| 69273 | Cyclin A/B1/B2 associated events during G2/M transition | 1.07 | 3.80E-04 | Reactome |
| WP441 | Matrix metalloproteinases | 1.05 | 7.59E-05 | Wiki |
| 5686938 | Regulation of TLR by endogenous ligand | 1.05 | 7.50E-03 | Reactome |
| 6791312 | TP53 Regulates Transcription of Cell Cycle Genes | 1.02 | 5.08E-05 | Reactome |
| WP1253 | Type II interferon signaling (IFNG) | 0.95 | 7.20E-04 | Wiki |
| 04657 | IL-17 signaling pathway | 0.91 | 1.23E-08 | KEGG |
| 04610 | Complement and coagulation cascades | 0.9 | 1.27E-08 | KEGG |
| 140877 | Formation of Fibrin Clot (Clotting Cascade) | 0.87 | 4.10E-03 | Reactome |
| mmu04115 | p53 signaling pathway | 0.8 | 1.30E-04 | KEGG |
| mmu04060 | Cytokine-cytokine receptor interaction | 0.77 | 8.20E-16 | KEGG |