Table 4.
Top Dysregulated KEGG Pathways in ALT-100 mAb-Treated Mice.
| Pathway ID | Term Description | Strength | False Discovery Rate |
|---|---|---|---|
| mmu 04061 | Viral protein interaction with cytokine and cytokine receptor | 1.06 | 1.23E-10 |
| mmu04060 | Cytokine-cytokine receptor interaction | 0.75 | 2.34E-10 |
| mmu 04657 | IL-17 signaling pathway | 0.97 | 5.59E-08 |
| mmu 04668 | TNF signaling pathway | 0.81 | 2.25E-05 |
| mmu 04110 | Cell cycle | 0.77 | 4.58E-05 |
| mmu 05323 | Rheumatoid arthritis | 0.85 | 5.45E-05 |
| mmu 04610 | Complement and coagulation cascades | 0.82 | 8.70E-05 |
| mmu 04062 | Chemokine signaling pathway | 0.66 | 0.0001 |
| mmu04115 | p53 signaling pathway | 0.85 | 0.00039 |
| mmu 04620 | Toll-like receptor signaling pathway | 0.75 | 0.0006 |
| mmu 04623 | Cytosolic DNA-sensing pathway | 0.79 | 0.0055 |
| mmu 04621 | NOD-like receptor signaling pathway | 0.54 | 0.0057 |
| mmu 05166 | Human T-cell leukemia virus 1 infection | 0.5 | 0.0078 |
| mmu 04064 | NF-kappa B signaling pathway | 0.65 | 0.0109 |
| mmu 05160 | Hepatitis C | 0.55 | 0.0125 |
| mmu 05206 | MicroRNAs in cancer | 0.5 | 0.0375 |
| mmu 05161 | Hepatitis B | 0.49 | 0.04 |
| mmu 05202 | Transcriptional misregulation in cancer | 0.46 | 0.04 |