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. 2022 Dec;10(23):1280. doi: 10.21037/atm-22-5444

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Gene regulatory network of TMED2/3/4/9 in breast cancer. (A,B) Genome alterations of TMED2/3/4/9 in breast cancer assessed by cBioportal database and the survival analysis between the altered and unaltered groups. (C) Upstream regulatory network of TMED2/3/4/9 and their common positively correlated genes was probed using Expression2kinases web tool, and the top transcription factors and protein kinases were displayed. (D) TMED2/3/4/9 and their co-associated miRNAs in breast cancer were extracted from LinkedOmics, and the network was generated by the software Cytoscape. TMED, transmembrane p24 trafficking protein; miRNA, microRNA; CNA, copy-number alteration; PPI, protein-protein interaction.