Table 1. Analysis of the association between the mRNA levels of TMED2/3/4/9 and immune cell infiltration in breast cancer by TIMER2.0 database.
| Immune cells | Algorithms | TMED2 | TMED3 | TMED4 | TMED9 |
|---|---|---|---|---|---|
| T cell CD8+ | TIMER | 0.233* | 0.08 | 0.146* | −0.024 |
| EPIC | 0.214* | −0.075 | 0.237* | −0.112# | |
| MCPCOUNTER | −0.098 | −0.152# | −0.084 | −0.031 | |
| CIBERSORT | −0.187# | −0.101# | −0.141# | −0.071 | |
| CIBERSORT−ABS | −0.121# | −0.162# | −0.089 | −0.047 | |
| QUANTISEQ | −0.052 | −0.17# | −0.058 | −0.037 | |
| XCELL | −0.012 | −0.174# | −0.039 | −0.068 | |
| Subtype | Naive_XCEL | −0.007 | −0.229# | −0.073 | −0.14# |
| Central memory_XCEL | 0.024 | −0.154# | −0.055 | −0.065 | |
| Effector memory_XCELL | −0.124# | −0.109# | −0.1 | −0.03 | |
| T cell follicular helper | CIBERSORT | −0.227# | −0.137# | −0.216# | −0.047 |
| CIBERSORT−ABS | −0.133# | −0.203# | −0.13# | −0.019 | |
| DC cells | Myeloid dendritic cell_TIMER | −0.173# | −0.066 | −0.093 | 0.13* |
| Myeloid dendritic cell_XCELL | −0.045 | −0.151# | −0.152# | 0.015 | |
| Myeloid dendritic cell_MCPCOUNTER | 0.004 | −0.182# | 0.039 | −0.103# | |
| Myeloid dendritic cell_QUANTISEQ | 0.207* | −0.08 | 0.097 | −0.081 | |
| Myeloid dendritic cell activated_XCELL | −0.111# | −0.135# | −0.187# | 0.044 | |
| Plasmacytoid dendritic cell_XCELL | −0.012 | −0.069 | −0.179# | 0.07 | |
| NK cells | NK cell_EPIC | −0.247# | −0.062 | −0.355# | 0.121* |
| NK cell_MCPCOUNTER | 0.017 | −0.238# | 0.01 | −0.066 | |
| NK cell_QUANTISEQ | −0.148# | −0.181# | 0.051 | −0.102# | |
| NK cell_XCELL | 0.051 | 0.004 | 0.053 | 0.06 | |
| NK cell activated_CIBERSORT | −0.221# | −0.062 | −0.198# | 0.001 | |
| NK cell activated_CIBERSORT−ABS | −0.199# | −0.109# | −0.175# | 0.02 | |
| Macrophage | EPIC | −0.061 | −0.075 | −0.129# | 0.172* |
| TIMER | 0.317* | 0.101* | 0.222* | 0.098 | |
| XCELL | 0.095 | 0.045 | −0.076 | 0.208* | |
| M0_CIBERSORT | −0.04 | 0.032 | −0.108# | 0.148* | |
| M0_CIBERSORT−ABS | −0.035 | −0.033 | −0.106# | 0.148* | |
| M1_CIBERSORT | 0.128* | −0.112# | −0.064 | −0.015 | |
| M1_CIBERSORT−ABS | 0.093 | −0.164# | −0.025 | −0.002 | |
| M1_QUANTISEQ | 0.139* | 0.055 | −0.007 | 0.124* | |
| M1_XCELL | −0.037 | 0.012 | −0.189# | 0.242* | |
| M2_CIBERSORT | 0.187* | 0.189* | 0.172* | 0.139* | |
| M2_CIBERSORT−ABS | 0.186* | −0.034 | 0.155* | 0.114* | |
| M2_QUANTISEQ | 0.078 | 0.022 | 0.178* | −0.023 | |
| M2_XCELL | 0.039 | 0.118* | −0.07 | 0.189* | |
| M2_TIDE | −0.116# | 0.097 | 0.03 | −0.086 | |
| Macrophage/Monocyte_MCPCOUNTER | 0.122* | −0.088 | −0.017 | 0.109* |
*, represents positive correlation (P<0.05 and Rho >0.1); whereas #, represents negative correlation (P<0.05 and Rho <−0.1). The regular numbers with colorless background indicate not significant. mRNA, messenger RNA; TMED, transmembrane p24 trafficking protein; DC, dendritic cells; NK, natural killer.