. 2022 Dec;10(23):1280. doi: 10.21037/atm-22-5444

Table 2. Correlation analysis of TMED2/3/4/9 mRNA levels and gene markers of immune cells in breast cancer.

Immune cells	Gene markers	TMED2	TMED3	TMED4	TMED9
T cell (general)	CD3D	−0.113^#	−0.195^#	−0.161^#	−0.009
	CD3E	−0.053	−0.207^#	−0.102^#	−0.052
	CD2	0.001	−0.201^#	−0.081	−0.028
CD8+ T cell	CD8A	0.008	−0.206^#	−0.013	−0.075
	CD8B	−0.098	−0.152^#	−0.084	−0.031
Tex	PD-1 (PDCD1)	−0.173^#	−0.19^#	−0.126^#	0.058
	CTLA4	−0.024	−0.203^#	−0.139^#	0.019
	LAG3	−0.128^#	−0.17^#	−0.201^#	0.089
	TIM-3 (HAVCR2)	0.186*	−0.061	0.042	0.137*
	GZMB	−0.058	−0.166^#	−0.209^#	0.039
B cell	CD19	−0.132^#	−0.143^#	−0.106^#	−0.048
	CD79A	−0.101^#	−0.149^#	−0.109^#	−0.073
NK cell	KIR2DL3	0.031	−0.12^#	−0.054	−0.017
	KIR2DL4	0.014	−0.134^#	−0.083	0.002
	KIR3DL1	0.002	−0.115^#	−0.043	0.016
	KIR3DL2	−0.027	−0.135^#	−0.109^#	−0.041
	KIR2DS4	0.029	−0.113^#	−0.063	−0.033
DC	HLA-DPB1	−0.193^#	−0.064	−0.096	0.119*
	HLA-DQB1	−0.113^#	−0.118^#	−0.132^#	0.089
	HLA-DRA	0.049	−0.11^#	−0.015	0.037
	BCDA-1 (CD1C)	−0.109^#	−0.111^#	0.015	−0.121^#
	BDCA-4 (NRP1)	0.235*	−0.019	0.182*	−0.065
TAM	CCL2	0.043	−0.128^#	−0.101^#	0.002
	CD68	0.149*	−0.036	0.029	0.192*
	IL10	0.197*	−0.093	0.016	0.162*
M1 macrophage	IRF5	0.056	−0.05	0.15*	0.18*
	COX2 (PTGS2)	0.044	−0.142^#	−0.012	−0.098
M2 macrophage	CD163	0.202*	−0.075	0.113*	0.199*
	VSIG4	0.092	−0.031	0.072	0.133*
	MS4A4A	0.17*	−0.085	0.056	0.118*

*, represents positive correlation (P<0.05 and Rho >0.1); whereas ^#, represents negative correlation (P<0.05 and Rho <−0.1). The regular numbers with colorless background indicate not significant. TMED, transmembrane p24 trafficking protein; mRNA, messenger RNA; DC, dendritic cells; NK, natural killer; TAM, tumor associated macrophages.