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. 2022 Dec 28;21:574–585. doi: 10.1016/j.csbj.2022.12.045

Table 3.

Highest frequency polymorphisms detected in core genes of colistin-resistant Acinetobacter baumannii isolates compared to the colistin-sensitive Acinetobacter baumannii isolates.

Protein name Function Gene locus tag in A. baumannii ACICU Frequency Amino Acid Change
Acetyl-coenzyme A synthetase Acs Acetyl-CoA biosynthesis ACICU_RS17860 37.40 % A565V
Aromatic ring-hydroxylating dioxygenase subunit alpha Oxidoreductase ACICU_RS10105 17.20 % R349H
NADPH-dependent 2,4-dienoyl-CoA reductase Flavoprotein oxidoreductase ACICU_RS10315 16.20 % A155V
Hypothetical protein Unknown function ACICU_RS11690 16.20 % R77H
AarF/UbiB family protein Protein phosphorylation ACICU_RS11940 37.40 % P82S
LemA family protein Integral component of membrane ACICU_RS17225 23.20 % A167E
ATP-binding protein Unknown function ACICU_RS13425 23.20 % D640A
Penicillin-binding protein 1B MrcB Regulation of cell shape, peptidoglycan synthesis ACICU_RS12655 16.20 % P545L
GntR family transcriptional regulator Transcription regulation ACICU_RS09030 16.20 % S39T
Alkene reductase NemA Xenobiotic reductase ACICU_RS17885 16.20 % D692G
PepP Proteolysis ACICU_RS05710 16.20 % Y800F
Peptide chain release factor 3 Protein biosynthesis ACICU_RS02980 17.20 % K231N
PmrB Signal transduction,
LPS modification
ACICU_RS15230 44.40 % A226V
16.20 % T269P
RpoA Transcription regulation ACICU_RS16580 37.40 % V59L
MotA/TolQ/ExbB proton channel family protein Integral component of membrane, transmembrane transport ACICU_RS02510 37.40 % A127T
PDR/VanB family oxidoreductase Oxidoreductase ACICU_RS10090 16.20 % I181M