Table 3.
Highest frequency polymorphisms detected in core genes of colistin-resistant Acinetobacter baumannii isolates compared to the colistin-sensitive Acinetobacter baumannii isolates.
| Protein name | Function | Gene locus tag in A. baumannii ACICU | Frequency | Amino Acid Change |
|---|---|---|---|---|
| Acetyl-coenzyme A synthetase Acs | Acetyl-CoA biosynthesis | ACICU_RS17860 | 37.40 % | A565V |
| Aromatic ring-hydroxylating dioxygenase subunit alpha | Oxidoreductase | ACICU_RS10105 | 17.20 % | R349H |
| NADPH-dependent 2,4-dienoyl-CoA reductase | Flavoprotein oxidoreductase | ACICU_RS10315 | 16.20 % | A155V |
| Hypothetical protein | Unknown function | ACICU_RS11690 | 16.20 % | R77H |
| AarF/UbiB family protein | Protein phosphorylation | ACICU_RS11940 | 37.40 % | P82S |
| LemA family protein | Integral component of membrane | ACICU_RS17225 | 23.20 % | A167E |
| ATP-binding protein | Unknown function | ACICU_RS13425 | 23.20 % | D640A |
| Penicillin-binding protein 1B MrcB | Regulation of cell shape, peptidoglycan synthesis | ACICU_RS12655 | 16.20 % | P545L |
| GntR family transcriptional regulator | Transcription regulation | ACICU_RS09030 | 16.20 % | S39T |
| Alkene reductase NemA | Xenobiotic reductase | ACICU_RS17885 | 16.20 % | D692G |
| PepP | Proteolysis | ACICU_RS05710 | 16.20 % | Y800F |
| Peptide chain release factor 3 | Protein biosynthesis | ACICU_RS02980 | 17.20 % | K231N |
| PmrB | Signal transduction, LPS modification |
ACICU_RS15230 | 44.40 % | A226V |
| 16.20 % | T269P | |||
| RpoA | Transcription regulation | ACICU_RS16580 | 37.40 % | V59L |
| MotA/TolQ/ExbB proton channel family protein | Integral component of membrane, transmembrane transport | ACICU_RS02510 | 37.40 % | A127T |
| PDR/VanB family oxidoreductase | Oxidoreductase | ACICU_RS10090 | 16.20 % | I181M |