Table 3.
Univariate and multivariate Cox proportional hazard analysis of clinical, laboratory, and imaging factors at baseline.
| Characteristics | Training cohort |
Test cohort |
||
|---|---|---|---|---|
| Hazard ratio | P value | Hazard ratio | P value | |
| Univariate Cox proportional hazard analysis | ||||
| Clinical factors | ||||
| Sex | 0.770 (0.359, 1.652) | 0.503 | 1.924 (0.619, 5.983) | 0.258 |
| Age | 1.008 (0.979, 1.037) | 0.604 | 1.024 (0.992, 1.056) | 0.139 |
| Disease location | 0.828 (0.635, 1.081) | 0.165 | 1.23 (0.9450, 1.602) | 0.124 |
| Smoking | 0.892 (0.402, 1.976) | 0.778 | 1.181 (0.410, 3.403) | 0.758 |
| Disease duration (months) | 1.003 (0.993, 1.013) | 0.562 | 1.006 (0.996, 1.016) | 0.226 |
| BMI (kg/m2) | 0.900 (0.789, 1.027) | 0.119 | 1.132 (0.972, 1.318) | 0.112 |
| Perianal fistula/abscess | 1.560 (0.723, 3.364) | 0.257 | 0.000 (0.000, Inf) | 0.998 |
| Drug history | ||||
| Biologics | 2.213 (0.297, 16.51) | 0.438 | 2.037 (0.557, 7.442) | 0.282 |
| Corticosteroids use 3 months ago | 0.999 (0.298, 3.355) | 0.999 | 0.548 (0.071, 4.219) | 0.564 |
| Immune preparations | 0.802 (0.273, 2.351) | 0.687 | 2.283 (0.637, 8.182) | 0.205 |
| Laboratory factors | ||||
| CRP (mg/L) | 1.009 (0.995, 1.023) | 0.199 | 1.004 (0.995, 1.013) | 0.376 |
| ESR (mm/h) | 0.999 (0.986, 1.011) | 0.851 | 1.003 (0.984, 1.022) | 0.792 |
| Albumin (g/L) | 0.952 (0.887, 1.023) | 0.179 | 0.923 (0.853, 0.999) | 0.047 |
| Hemoglobin (g/L) | 0.990 (0.974, 1.005) | 0.192 | 0.996 (0.975, 1.017) | 0.688 |
| Platelet (×10ˆ9/L) | 1.000 (0.997, 1.003) | 0.868 | 0.999 (0.995, 1.003) | 0.748 |
| Adipose tissue metrics | ||||
| VAT volume | 1.000 (1.000, 1.000) | 0.700 | 1.000 (1.000, 1.000) | 0.821 |
| SAT volume | 1.000 (1.000, 1.000) | 0.781 | 1.000 (1.000, 1.000) | 0.970 |
| Visceral to subcutaneous fat volume ratio | 1.072 (0.606, 1.895) | 0.812 | 0.958 (0.865, 1.06) | 0.408 |
| Visceral to subcutaneous fat area ratio at L3 | 0.455 (0.174, 1.192) | 0.109 | 0.876 (0.628, 1.221) | 0.434 |
| Visceral to subcutaneous fat area ratio at L4 | 0.589 (0.200, 1.731) | 0.336 | 0.847 (0.511, 1.403) | 0.518 |
| Radiomic models | ||||
| VAT-RM | 16.339 (5.649, 47.26) | <0.001 | 17.203 (3.890, 76.078) | <0.001 |
| SAT-RM | 7.516 (3.496, 16.16) | <0.001 | 6.072 (1.952, 18.889) | 0.002 |
| Multivariate Cox proportional hazard analysis | ||||
| VAT-RM | 12.515 (3.897, 40.192) | <0.001 | 9.285 (1.962, 43.940) | 0.005 |
| SAT-RM | 2.189 (0.896, 5.351) | 0.086 | 3.280 (0.952, 11.300) | 0.060 |
| Albumin (g/L) | 0.957 (0.860, 1.064) | 0.415 | 0.899 (0.815, 0.993) | 0.036 |
Bolded value of P < 0.100 was considered statistical significance for univariate Cox proportional hazard analysis.
Bolded value of P < 0.050 was considered statistical significance for multivariate Cox proportional hazard analysis.
BMI, body mass index; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; RM, radiomic model; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue.