FIGURE 1.

The dynamic process of m6A modification and diverse functions of m6A readers. (A) Methyl was installed at N6 of adenosine by m6A methyltransferase complex which consists of METTL3, METTL14, WTAP, RBM15, VIRMA and ZC3H13. In addition, METTL16 and NSun2 could function individually. M6A modification could be removed by demethyltransferases FTO and ALKBH5. m6A writers and erasers dynamically regulate RNA m6A levels, followed by recognition of m6A binding proteins. Different readers manipulate diverse RNA metabolism processes. (B) In the nucleus, readers could mediate mRNA alternative splicing, maintain mRNA stability and primary miRNAs processing. (C) In the cytoplasm, readers could promote mRNAs translation and the exact opposite function, mRNAs degradation