TABLE 1.

Functions of m6A regulators

Type	Regulator	Function	Ref.
Writer	METTL3	Catalyses m6A modification	19
	METTL14	Provides a platform for METTL3's catalysis	20
	METTL16	Catalyses m6A modification	27
	WTAP	Binds to METTL3‐METTL14 complex and recruits it to nuclear speckle	21, 22
	VIRMA	Recruits METTL3‐METTL14‐WTAP complex to 3′UTR and stop codon region	23
	RMB15/RMB15B	Connect with the METTL3‐WTAP complex for XIST silencing	24, 25
	ZC3H13	Bridge RBM15 to WTAP‐VIRMA complex	26
	NSun2	Catalyses m6A modification	28
Eraser	FTO	Removes m6A modification	29, 30
	ALKBH5	Removes m6A modification	31
Reader	YTHDF1	Accelerates translation or promotes stability and storage of transcripts	33
	YTHDF2	Promotes mRNAs and pre‐miRNAs decay	34
	YTHDF3	Coordinates with YTHDF1 and YTHDF2 to exert their own effects	35
	YTHDC1	Assists mRNA precursor export to the cytoplasm	36, 37
	YTHDC2	Enhances translation efficiency and decreases mRNA abundance; decreases target mRNAs translation	38, 39
	HNRNPA2B1	Mediates mRNAs alternative splicing and pri‐miRNAs processing	41
	HNRNPC	Mediates mRNAs splicing	33
	IGF2BP1	Promotes mRNAs translation and stability	42
	EIF3	Promotes mRNAs translation	43
	NKAP	Mediates pri‐miRNAs processing	44