TABLE 4.

The interaction between m6A erasers and miRNAs

M6A regulators	Cancer type	miRNA	Erasers' role	Mechanism	Validation approach/model	Function of erasers	Ref
FTO	Breast cancer	miR‐181‐3p	Oncogene	Processing↓	Not in m6A‐dependent way	Promote metastasis‐related adhesion	69
FTO	NSCLC	miR‐607	Oncogene	miRNA target erasers 3′UTR	Dual luciferase report assay, miRNA mimic/inhibitor (cell)	Promote tumorigenesis and invasion	70
ALKBH5	Osteosarcoma	miR‐181b‐3p	Suppress	Processing↑	MeRIP‐qPCR (cell)	Inhibit YAP expression	71
ALKBH5	Oesophageal cancer	miR‐193a‐3p	Oncogene	Processing↑ miRNA target erasers 3′UTR	MeRIP‐qPCR, dual luciferase report assay (cell)	Promote cancer cell proliferation and metastasis	47
ALKBH5	Glioma	miR‐193a‐3p	Suppress	miRNA target erasers 3′UTR	Dual luciferase report assay, miRNA mimic/inhibitor (cell)	Stimulate AKT2/Bcl2/survivin, inhibit intrinsic apoptosis	49
ALKBH5	Ovarian cancer	miR‐7	Oncogene	miRNA target erasers 3′UTR	HuR‐dependent (cell)	Stimulate EGFR‐PI3K/AKT/mTOR pathway	72

Abbreviations: MeRIP‐qPCR, methylated RNA immunoprecipitation quantitative polymerase chain reaction; NSCLC, non‐small cell lung cancer; processing↑, promote pri‐miRNAs processing; processing↓, inhibit pri‐miRNAs processing.