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. Author manuscript; available in PMC: 2023 Jan 6.
Published in final edited form as: Mod Pathol. 2021 Sep 20;35(3):333–343. doi: 10.1038/s41379-021-00896-6

Figure 1. Histologic characteristics of LOT.

Figure 1.

Representative H&E images from LOT reveal a well circumscribed partly encapsulated eosinophilic tumor (white arrow) (A) composed of homogenous cells arranged in sheets of tight nests (B) with focal edematous areas with loose cords of tumor cells (C), and occasional dilated vascular channels and hemorrhage (D). High-power images show that the tumors are uniformly composed of cells with abundant finely granular eosinophilic cytoplasm, indistinct cell borders, round nuclei with relatively smooth membranes, subtle perinuclear clearing and binucleation (E). Lymphoid clusters are frequent (F). Representative immunohistochemical profile of CD117 with only scattered positive mast cells (G), and cytokeratin 7, which is strong and diffusely positive (H).