Table 1.
Clinicopathologic Characteristics of LOT Cases in the Cohort
| Patient ID | Age | Sex | Presentation | Family History | Other Significant Medical History | Original Diagnosis | Nephrectomy | Laterality | Tumor Size (cm) | Focality (number) | pT | pN | Stage | Metastasis | Follow-up (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LOT 1 | 79 | F | Back pain | None | Contralateral metastatic ccRCC | ChRCC-eo | Partial | Right | 7.8 | Unifocal | pT2a | pNx | II | No | Deceased (26) |
| LOT 2 | 86 | F | Incidental | None | None | ChRCC-eo | Radical | Right | 6.5 | Unifocal | pT1b | pNx | I | No | ALF (3) |
| LOT 3a | 63 | F | Anemia | Father with b/l Nx for unknown reason | B/l multiple LOTs | ChRCC-eo | Partial | Right | 4.0, 2.3, 1.5, 1.4, 0.8, 0.5 | Multifocal (6) | pT1a* | pNx | I | No | ALF (37) |
| LOT 3b | ChRCC-eo | Partial | Left | 5.3, 5.2, 4.9, 3.7, 2.1, 2.0, 1.9, 1.6, 1.0, 0.9 | Multifocal (10) | pT1b* | pNx | I | No | ||||||
| LOT 4 | 69 | M | Hematuria | None | None | ChRCC-eo | Partial | Right | 2.3 | Unifocal | pT1a | pNx | I | No | ALF (29) |
| LOT 5 | 71 | F | Incidental | None | Prior contralateral nephrectomy for benign tumor | ChRCC-eo | Partial | Right | 3.8 | Unifocal | pT1a | pNx | I | No | ALF (53) |
| LOT 6 | 75 | F | Incidental | None | None | ChRCC-eo | Partial | Left | 2.4 | Unifocal | pT1a | pNx | I | No | Deceased (36) |
| LOT 7 | 84 | M | Incidental | None | Contralateral renal mass followed with AS | ChRCC-eo | Radical | Right | 6.5 | Unifocal | pT1b | pNx | I | No | Deceased (29) |
ccRCC: clear cell renal cell carcinoma; B/l: bilateral; Nx: nephrectomy; AS: active surveillance; ChRCC-eo: chromophobe renal cell carcinoma, eosinophilic variant
*
: pT represents the highest stage
ALF: alive at last follow-up.