Table 6.
Effect of various clinical characteristics, laboratory data and tumor features on serum gastrin levels calcium stimulation in 208 patients seen at NIH and 212 ZES patients from the literature.
| Δ Calcium (pg/ml)* | ||||||
|---|---|---|---|---|---|---|
| NIH | Literature† | |||||
|
|
|
|||||
| Variable‡ | Variable Present | Variable Absent | p | Variable Present | Variable Absent | p |
|
| ||||||
| Age at evaluation > 48 years | ||||||
| median [range] | 865 [−10–75250] | 835 [−166–208000] | 0.78 | 1000 [0–116047]] | 1000 [0–95000] | 0.41 |
| Male gender | ||||||
| median [range] | 1453 [−10–25105] | 3825 [−166–208000] | 0.016§ | 912 [0–95000] | 1121 [0–116047] | 0.15 |
| MEN1 | ||||||
| median [range] | 1222 [−166–17590] | 774 [−10–208000] | 0.25 | 980 [48–116047] | 980 [0–95000] | 0.66 |
| Prior acid-reducing surgery | ||||||
| median [range] | 1230 [0–53600] | 826 [−166–208000] | 0.24 | 1115 [68–92140] | 980 [0–168000] | 0.33 |
| BAO > 15 (prior acid-reducing surgery) | ||||||
| Median [Range] | 535 [0–53600] | 4420 [705–25105] | 0.0013§ | 975 [68–22724] | 912 [145–92140] | 0.74 |
| MAO > 51 (no prior acid-reducing surgery) | ||||||
| Median [Range] | 850 [−166–208000] | 701 [1–46000] | 0.92 | 1595 [0–168000] | 980 [0–7993] | 0.15 |
| Primary tumor size > 1.5 cm (all pts.) | ||||||
| Median [Range] | 1182 [0–208000] | 697 [15–17590] | 0.17 | No Data** | No Data | |
| Primary tumor size ≥ 3 cm (all pts.) | ||||||
| Median [Range] | 838 [0–75250] | 888 [1–208000] | 0.58 | No Data | No Data | |
| Primary localization pancreas | ||||||
| Median [Range] | 958 [0–75250] | 814 [1–208000] | 0.79 | 691 [48–29000] | 1170 [0–95000] | 0.80 |
| Primary localization duodenum | ||||||
| Median [Range] | 698 [1–208000] | 1035 [0–75250] | 0.60 | 1170 [0–9890] | 691 [48–95000] | 0.85 |
| Localized disease†† | ||||||
| Median [Range] | 850 [−166–208000] | 602 [0–53600] | 0.28 | 1122 [0–28650] | 1235 [0–95000] | 0.87 |
Abbreviations: See Table 1. Pts., patients; mts., metastases.
‘Δ Calcium’ corresponds to the maximal absolute change in serum gastrin levels (expressed in pg/ml) after infusion of 5 mg/kg/hr. calcium for 3 hours. Indicated are the median and the range for each group of patients.
Literature data are from publications listed in Table 2.
For continuous variables, the median of the total population (NIH+literature) is used to divide the patients into 2 groups.
indicates a significant difference (p<0.05).
‘No Data’ indicates that information was available on less than 10 patients.
‘Localized disease’ includes all patients without evidence for liver or other distant metastases.