Table 8.
Influence of clinical variables, acid secretion data and tumor features on the results of the secretin stimulation test in 280 ZES-patients seen at NIH and 355 patients from the literature.
| Variable present* | ||||||
|---|---|---|---|---|---|---|
| NIH | Literature† | |||||
|
|
|
|||||
| Variable‡ | Δ Secretin ≥ 200 | Δ secretin < 200 | p | Δ Secretin ≥ 200 | Δ secretin < 200 | p |
|
|
|
|||||
| Age ≥ 48 years | 131 (53) | 15 (43) | 0.24 | 131 (50) | 23 (62) | 0.15 |
| Male gender | 137 (56) | 22 (55) | 0.97 | 156 (60) | 8 (19) | <0.0001§ |
| MEN1 present | 71 (29) | 12 (30) | 0.31 | 56 (18) | 6 (9.5) | 0.50 |
| Previous acid-reducing surgery | 38 (16) | 4 (10) | 0.62 | 57 (18) | 19 (51) | <0.0001§ |
| BAO > 35 (no acid-reducing surgery) | 120 (60) | 17 (52) | 0.23 | 67 (49) | 9 (47) | 0.92 |
| MAO > 51 (no acid-reducing surgery) | 110 (63) | 18 (58) | 0.47 | 38 (45) | 4 (40) | >0.99 |
| Primary size > 1.5 cm (all patients) | 71 (39) | 13 (65) | 0.027§ | 21 (44) | 1 (20) | 0.39 |
| Primary size > 1.3 cm (no liver metastases) | 63 (42) | 4 (44) | >0.99 | 22 (49) | 0 (0) | 0.11 |
| Primary size ≤ 1 cm (all patients) | 90 (50) | 7 (35) | 0.2 | 24 (50) | 8 (44) | 0.69 |
| Primary size ≤ 1 cm (no liver metastases) | 78 (52) | 5 (55) | >0.99 | 28 (56) | 4 (22) | 0.10 |
| Primary size ≥ 3 cm (all patients) | 40 (22) | 9 (35) | 0.023§ | 14 (29) | 7 (39) | 0.42 |
| Primary size ≥ 3 cm (no liver metastases) | 24 (26) | 3 (25) | 0.18 | 11 (24) | 13 (65) | 0.0018§ |
| Pancreatic primary tumor | 65 (28) | 15 (37) | 0.17 | 61 (47) | 8 (44) | 0.84 |
| Duodenal primary tumor | 99 (40) | 8 (20) | 0.0017§ | 50 (38) | 7 (39) | 0.97 |
| Other primary tumor | 32 (13) | 3 (7.5) | 0.59 | 22 (17) | 4 (22) | 0.52 |
| Localized disease | 212 (86) | 26 (72) | 0.026§ | 111 (74) | 13 (65) | 0.37 |
Abbreviations: see table 1.
Indicated is the number and percentage of patients with the indicated variable present, subdivided according to the secretin stimulation test. Data for literature patients is derived from the publications cited in Figure 1. The total number of patients in each group can be calculated using the number and percentage values.
Literature data are from publications listed in Table 2.
For continuous variables, the median of the total population (NIH + Literature) is used to divide patients into 2 groups.
indicates a significant difference (p<0.05).