FIGURE 7.

In vivo validation of lonicerin for the treatment of asthma by inhibiting the Src/EGFR pathway. (A–E) Detection of mRNA expression of Src, EGFR, p53, TNF-α and KDR in lung tissues of different groups of mice by qPCR. (n = 4–5). (F) Lung tissues from each group were extracted for Western blot to analyse the protein levels of p-EGFR, EGFR, p-Src and Src. (G,H) The corresponding quantification histograms of (F). (n = 4). Data are expressed as mean ± SEM. Differences between groups were determined with one‐way ANOVA followed by the Tukey’s post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001 vs. Control group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. HDM group.