Table 1.

Different viral proteins to suppress cGAS-stimulator of interferon genes (STING) pathway.

Viral protein	Function	References
VP1-2	Deubiquitinates STING	Bodda et al. (2020)
VP16	Binds to p65 to inhibit NF-κB activation	Xing et al. (2013)
VP22	Inhibits the enzymatic activity of cGAS	Huang et al. (2018)
VP24	Inhibits the phosphorylation and dimerization of IRF3	Zhang et al. (2016)
ICP0	Binds to p65/p50 to inhibit NF-κB activation	Zhang et al. (2013a)
ICP27	Binds to IκBα to inhibit NF-κB activation	Kim et al. (2008)
US3	hyperphosphorylated p65 to inhibit NF-κB activation	Wang et al. (2014)
UL24	Reduces the nuclear translocation of p65/p50 to inhibit NF-κB activation	Xu et al. (2017)
UL42	Binds to p65/p50 to inhibit NF-κB activation	Zhang et al. (2013b)
UL37	Inhibits the activation of cGAS	Zhang et al. (2018)
UL41	Decreases cGAS expression	Su and Zheng (2017)
UL46	Reduces TBK1 activation	You et al. (2019)

STING, stimulator of interferon genes; cGAS, cyclic GMP–AMP synthase; IRF3, interferon regulatory factor 3; NF-κB, nuclear factor-κappa B; IκBα, inhibitor of NF-κB; TBK1, TANK-binding kinase 1.