Fig. 3.

During the period of leuprolide exposure, estrous cyclicity was halted after vaginal opening. Saline controls entered estrus within 4 days of vaginal opening, whereas leuprolide-treated female rats failed to enter estrus after vaginal opening during treatment (saline: n = 14; leuprolide: n = 7). Data are presented as the mean number of days until first estrus after vaginal opening for each group (± SEM); n = number of subjects in each group