Table 2.
Patient presentations by group on days 8 and 15
| Treatment group (D8) n = 20 | Control group (D8) n = 20 | p-valuea | |||
|---|---|---|---|---|---|
| Median (IQR) | Mean ± SD | Median (IQR) | Mean ± SD | ||
| Body weight (kg) | 0.0(0.0 to 0.0) | 0.25 ± 0.64 | 0.0(0.0 to 0.0) | 0.28 ± 1.14 | 0.433 |
| SBP (mmHg) | 1.00(− 10.0 to 7.8) | 0.60 ± 13.11 | 1.0(− 7.8 to 7.3) | 2.30 ± 11.98 | 0.745 |
| DBP (mmHg) | 0.00(− 5.8 to 3.5) | 0.40 ± 8.31 | 0.0(− 7.5 to 6.0) | 1.80 ± 14.62 | 0.903 |
| WBC (/μl) | − 960(− 2622.5 to − 55.0) | − 1392 ± 1505 | − 1120(− 2642.5 to − 177.5) | − 1368.5 ± 1774.3 | 0.903 |
| RBC (104/μl) | 6.0(0.0–20.3) | 10.30 ± 19.02 | − 4.0(− 11.3 to 9.3) | − 0.25 ± 18.31 | 0.042* |
| Hb (g/dl) | 0.0(− 0.1 to 0.7) | 0.31 ± 0.67 | − 0.1(− 0.4 to 0.4) | − 0.02 ± 0.52 | 0.139 |
| Hct (%) | 0.5(− 0.2 to 2.0) | 0.88 ± 1.68 | − 0.2(− 1.6 to 1.0) | −0.26 ± 1.78 | 0.047* |
| MCV (fl) | 0.0(− 0.4 to 0.5) | 0.01 ± 0.64 | − 0.3(− 1.0 to 0.3) | − 0.42 ± 0.81 | 0.143 |
| MCH (Pg) | 0.0(− 0.4 to 0.3) | − 0.02 ± 0.44 | − 0.1(− 0.5 to 0.4) | − 0.01 ± 0.46 | 0.968 |
| MCHC (g/dl) | 0.0(− 0.4 to 0.4) | − 0.03 ± 0.44 | 0.1(− 0.2 to 0.6) | 0.13 ± 0.53 | 0.408 |
| Platelet (/μl) | 11.5 K(− 6.5 K to 27.5 K) | 10750 ± 26098.7 | 8 K(− 6.5 K to 25.3 K) | − 900 ± 47901.1 | 0.787 |
| GPT (IU/l) | 0.0(− 3.8 to 7.3) | 1.15 ± 7.68 | 4.5(− 1.8 to 26.8) | 11.40 ± 18.36 | 0.107 |
| Creatine (mg/dl) | 0.1(0.0 to 0.2) | 0.07 ± 0.12 | 0.02(0.0 to 0.1) | 0.06 ± 0.12 | 0.494 |
| CRP (mg/dl) | − 0.2(− 0.9 to 0.0) | − 0.55 ± 1.11 | − 0.4(− 1 to − 0.1) | − 1.00 ± 1.96 | 0.336 |
| Uric acid (mg/dl) | − 1.9(− 3.7 to 0.0) | − 1.77 ± 2.037 | 0.8(− 0.1 to 2.2) | 1.24 ± 2.084 | < 0.001*** |
| VAS | − 5.5(− 8.0 to − 3.0) | − 5.2 ± 3.09 | − 3.5(− 5.9 to − 2.0) | − 3.63 ± 2.38 | 0.080 |
| Treatment group (D15) n = 20 | Control group (D15) n = 20 | p-valuea | |||
|---|---|---|---|---|---|
| Median (IQR) | Mean ± SD | Median (IQR) | Mean ± SD | ||
| Body weight (kg) | 0.0(0.0 to 0.0) | 0.20 ± 0.70 | 0.0(0.0 to 0.0) | 0.06 ± 0.34 | 0.638 |
| SBP (mmHg) | 0.5(− 6.8 to 7.8) | − 0.25 ± 9.78 | 2.5(− 13.3 to 5.5) | − 1.30 ± 13.09 | 0.892 |
| DBP (mmHg) | − 0.5(− 6.0 to 5.3) | − 1.15 ± 11.39 | 0.0(− 12.3 to 5.5) | − 1.85 ± 11.53 | 0.946 |
| WBC (μl) | − 1115(− 2805 to 0.0) | − 1394 ± 1820.5 | − 1200(− 2682.5 to − 225.0) | − 1266.5 ± 2261.4 | 0.892 |
| RBC (104/μl) | 2.0(− 17.8 to 18.5) | 1.45 ± 19.69 | 4.0(− 10.0 to 11.5) | 2.20 ± 18.02 | 0.946 |
| Hb (g/dl) | 0.1(− 0.6 to 0.5) | 0.01 ± 0.57 | 0.1(− 2.0 to 0.4) | − 0.02 ± 0.52 | 0.870 |
| Hct (%) | 0.0(− 1.7 to 1.5) | 0.05 ± 1.56 | 0.1(− 1.3 to 1.2) | − 0.07 ± 1.78 | 0.989 |
| MCV (fl) | − 0.1(− 0.4 to 0.1) | – 0.23 ± 0.50 | − 0.8(− 1.0 to 0.4) | − 0.49 ± 1.06 | 0.316 |
| MCH (Pg) | − 0.1(− 0.4 to 0.3) | − 0.11 ± 0.44 | –0 .1(− 0.4 to 0.1) | − 0.15 ± 045 | 0.786 |
| MCHC (g/dl) | 0.0(–0 .3 to 0.4) | − 0.02 ± 0.44 | − 0.1(− 0.3 to 0.3) | − 0.01 ± 0.59 | 0.645 |
| Platelet (μl) | 8 K(− 22.3 K–27.8 K) | 5050 ± 28943.6 | 2 K(− 8.3 K–21.5 K) | − 16800 ± 76110.4 | 0.579 |
| GPT (IU/l) | 0.0(− 2.0 to 4.8) | 1.20 ± 5.90 | 7.0(− 0.8 to 15.5) | 10.50 ± 17.77 | 0.029* |
| Creatine (mg/dl) | 0.0(0.0 to 0.1) | 0.02 ± 0.14 | 0.0(− 0.1 to 0.1) | 0.04 ± 0.11 | 0.741 |
| CRP (mg/dl) | − 0.3(− 1.1 to 0.0) | − 0.89 ± 1.53 | − 0.5(− 1.4 to − 0.2) | − 01.12 ± 2.02 | 0.213 |
| Uric acid (mg/dl) | − 1.7(− 2.9 to 0.0) | − 1.36 ± 1.82 | 0.3(− 0.2 to 1.0) | 0.81 ± 2.09 | 0.002** |
| VAS | − 5.5(− 8.0 to − 3.1) | − 5.68 ± 3.01 | − 4.8(− 7.0 to − 2.0) | − 4.37 ± 2.86 | 0.161 |
BMI body mass index, CRP C-reactive protein, DBP diastolic blood pressure, GPT glutamic pyruvic transaminase, Hb hemoglobin, Hct hematocrit, MCH mean corpuscular hemoglobin, MCV mean corpuscular volume, RBC red blood cell, SBP systolic blood pressure, WBC white blood cell, IQR Interquartile range
aMann–Whitney U test for the difference compared between the treatment group and control group
*P < 0.05, **P < 0.01, ***P < 0.001