NCT04802096.

Study name	Effects of inspiratory muscle training in addition to pulmonary rehabilitation in patients with moderate to severe COPD exacerbation
Methods	Study design: RCT Study grouping:parallel‐group
Participants	Inclusion criteria Age > 20 years old Diagnosed as moderate exacerbation of COPD MIP < 80 cmH2O Exclusion criteria Any clinical diagnosis that will influence the measurement, including any history of neuromyopathy Angina, acute myocardial infarction in the previous  month Pregnancy Participated in IMT program in the previous 3 months Any psychiatric or cognitive disorders, e.g. Mini‐Mental State Examination < 24, that will disturb the communication and co‐operation of the study
Interventions	PR+IMT: PR: aerobic exercise training, strength training, and education related to airway clearance and drug utilization. All the participants will receive 8‐week PR IMT: the intensity of IMT will be set at 30% of MIP. Participantsin this group will perform 15 breaths/set, 6 sets/d on a daily basis. The intervention will last for 8 weeks PR: this group will undergo the same PR program as the intervention group
Outcomes	Functional exercise capacity: 6MWD HRQoL: SGRQ HRQoL: CAT
Starting date	15 March 2021
Contact information	Sponsorship source: National Taiwan University Hospital Country: Taiwan  Author's name: Wei‐Yu Huang Institution: School and Graduate Institute of Physical Therapy of National Taiwan University Email:  r08428013@ntu.edu.tw Address: Taipei, Zhongzheng Dist, Taiwan, 100 Clinical trial register: NCT04802096
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