RBR‐10nyzcqc.

Study name	Effects of Inspiratory Muscle Training on Breathlesness, Exercise Capacity and Postural Control in Patients with COPD
Methods	Study design: RCT Study grouping:parallel‐group
Participants	Inclusion criteria Age> 40 years  Diagnosis of COPD according to GOLD (2016) Absence of exacerbations in the last 30 days  Presence of inspiratory muscle weakness (PImax <70cmH2O or <70% of predicted) Exclusion criteria Diagnosis of psychiatric or cognitive diseases that compromise the understanding of the study's guidelines Progressive neurological disease  Neuromuscular disease; Vestibular disorders Orthopedic changes that compromise the results of field and range tests Presence of other comorbidities that, at the researcher's discretion, may interfere with the results of the study
Interventions	IMT: 22 patients will train at around 50% of their PImax. The training consists of 30 breaths in a row, with deep and strong inspiration (lasting 4‐5 minutes), twice a day, every day for 8 weeks. Each week, the patient will return to our center to perform a new manovacuometry and update the load value, maintaining the ~ 50% of the PImax value, and after this update, one of the sessions of the day will be held in person. Sham IMT: 16 patients will train at around 10% of their PImax. The training consists of 30 breaths in a row, with deep and strong inspiration (lasting 4‐5 minutes), twice a day, every day for 8 weeks. Every week, the patient will return to our center to perform a new manovacuometry, the data will be recorded, however the load will be kept at around 10% of the initial PImax value, after this registration, one of the sessions of the day will be held in person. This value will not make any changes during the study period. After the eight‐week protocol, patients will return to perform the initial evaluations and tests again, in the same order they did the first time, and will receive a new medical order for serum vitamin D and calcium measurement for comparison with the first. The CG participants after the study period will undergo the same protocol applied to the IG as treatment.
Outcomes	Dyspnea: mMRC Functional exercise capacity: 6MWD
Starting date
Contact information	yves.souza@uva.br
Notes