TCTR20210604001.

Study name	Is single bout of inspiratory muscle training alter blood pressure and cardio autonomics modulation in COPD patients? : a pilot study
Methods	Study design: RCT Study grouping: parallel‐group
Participants	Inclusion criteria GOLD stage 2‐3 COPD patients, which was defined by FEV1 30%‐80%pred Free of acute exacerbation of COPD > 8 weeks before the study BMI 18.5 kg/m2‐29.9 kg/m2 Exclusion criteria History of recent lung surgery, spontaneous pneumothorax or rib fracture < 12 months prior to the study History of stroke, diabetes, cardiovascular or neuromuscular disorder Resting blood pressure > 180/110 mmHg or < 90/60 mmHg Fracture at upper, lower extremity or spine < 6 months prior to the study Lower extremity and spine pain which was assessed by visual analog scale > 3  Regular exercise which was defined as having exercise or perform physical activity Unable to communicate and follow instructions Resting supplemental oxygen Age minimum: 40 years Age maximum: 70 years Gender: male
Interventions	Intervention characteristics IMT: participants will perform single session of IMT exercise with 60% of MIP. They will complete 6 breaths/set for 5 sets with 1‐min rest between each set Sham IMT: participants will undergo the same program described above at no load
Outcomes
Starting date	11 January 2021
Contact information	Sponsorship source: Khon Kaen University Khon Kaen, Thailand Country: Thailand Author's name: EAKARACH WONGSAYA Institution: School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University Email: eakarach.wo@up.ac.th Address: 123 School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University University 40002 Khon Kaen Thailand Clinical trial register: TCTR20210604001
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