Table 5.

Determinants of short time to diagnosis

Variables	Univariable analysis		Multivariable analysis
	HR (95% CI)	P	HR (95% CI)	P
Age at diagnosis, y [vs. 1st half (2.6–8.8)]
2nd half (8.8–15.3)	0.31 (0.13–0.76)	0.011	0.34 (0.13–0.88)	0.026
Sex (female)	0.91 (0.44–1.88)	0.800
Comorbiditya	1.44 (0.64–3.28)	0.380
Distance from the tertiary care hospitalb	0.49 (0.16–1.52)	0.219	0.27 (0.08–0.92)	0.036
Number of healthcare visits before diagnosis	0.77 (0.49–1.20)	0.249
GP as the first consulted physicianc	1.30 (0.59–2.90)	0.517
Late periodd	1.62 (0.74–3.56)	0.232	2.48 (1.05–5.85)	0.038
Children with clinical Kawasaki criteria	1.89 (0.76–4.67)	0.171	1.89 (0.70–5.11)	0.210

Data with significant P values < 0.05 were indicated in bold

aHR adjusted hazard ratio, GP general practitioner, HR hazard ratio, MIS-C multisystem inflammatory syndrome in children, 95% CI 95% confidence interval

^aAt least one comorbidity including asthma, obesity or organ malformation

^bDistance was analyzed as (value in km)/100

^cVs. emergency physician

^dThe late period was defined as the period after the implementation of the new French therapeutic guidelines on March 18, 2021