Table 2.
Institutions’ conduction system pacing outcomes for bradycardia pacing indications
| His | LBBAP | ||||
|---|---|---|---|---|---|
| Short-Term Outcomes [Nall cases = His/LBBAP] | All Cases | 2019 Cases | All Cases | 2019 Cases | P Value* |
| Intraprocedural Success [N = 75/46]† | 75% (60–90%) | 80% (60–90%) | 81% (50–95%) | 88% (50–95%) | 0.38 |
| Selective CSP [N = 76/44]‡ | 43% (26–60%) | 45% (23–65%) | 37% (10–70%) | 45% (7–83%) | 0.57 |
| CSP Threshold (V) [N = 60/41]‡,§ | 1.5 (1.3–2.0) | 1.4 (1.3–1.5) | 0.8 (0.6–1.0) | 0.7 (0.6–0.8) | 0.0008 |
| Ventricular Sensing (mv) [N = 69/45]‡ | 4.0 (3.0–5.0) | 4.0 (3.0–5.0) | 10.0 (7.0–12.0) | 10.0 (7.0–11.0) | < 0.0001 |
| Procedure Duration (minutes) [N = 63/39]¶ | |||||
| CSP | 80 (60–100) | 80 (64–110) | 75 (60–100) | 70 (58–90) | 0.78 |
| Non-CSP | 50 (35–65) | 48 (35–65) | 60 (40–65) | 55 (40–61) | 0.39 |
| Lead Revision (acute) [N = 69/46]‡ | 2.5% (0–8.0%) | 0.3% (0–5.0%) | 0% (0–5.0%) | 0% (0–3.0%) | 0.69 |
| Long-Term Outcomes [Nall cases = His/LBBAP] | |||||
| CSP Threshold [N = 58/37]‡,# | |||||
| Threshold (V) | 1.6 (1.3–2.0) | - | 0.7 (0.6–1.0) | - | < 0.0001 |
| Follow-Up (months) | 12 (9–20) | - | 7 (6–12) | - | 0.0019 |
| Lead Revision (chronic) [N = 49/31]‡,# | |||||
| Revision | 5.0% (1.0–10.0%) | - | 0.0% (0.0–1.0%) | - | 0.0001 |
| Time To Revision (months) | 6 (3–12) | - | 3 (1–5) | - | 0.0490 |
| Pacing Induced Cardiomyopathy [N = 51/37]‡,# | |||||
| Cardiomyopathy (mean ± SD) | 1.1 ± 4.0% | - | 2.1 ± 7.4% | - | 0.40 |
| Ventricular Pacing Burden | 85% (61–95%) | - | 90% (80–100%) | - | 0.76 |
| Time To Cardiomyopathy (months) | 12 (8–24) | - | 6 (4–11) | - | 0.17 |
Values are median (interquartile range) or n (%) unless otherwise specified. CSP: conduction system pacing, LBBAP: left bundle branch area pacing, SD: standard deviation
*Difference between all His and LBBAP cases assessed with the χ2 and 2-sample t test for categorical and continuous variables, respectively
†Success defined as selective or non-selective His or left bundle branch capture with threshold less than 2.5 V @ 1.0 ms or 1.5 V @ 0.5 ms, respectively
‡For CSP cases with intraprocedural success
§CSP capture threshold defined as loss of His or left bundle branch capture at @1.0 ms or 0.5 ms, respectively. Not loss of myocardial capture
¶Procedure duration for transvenous pacemakers without cardiac resynchronization
#Last available follow-up