Table 1.
Patient, Tumor, and Treatment Characteristics
| Variable | All patients (n=120) Value or number (%) |
|---|---|
| Patient characteristics | |
| Age, years | |
| Median | 60 |
| IQR | 48–69 |
| Sex | |
| Female | 50 (42) |
| Male | 70 (58) |
| BMI, kg/m2 | |
| Median | 30 |
| IQR | 26–33 |
| Diabetes mellitus | |
| No | 105 (88) |
| Yes | 15 (13) |
| Tobacco smoking status | |
| Active smoker at diagnosis | 7 (6) |
| History of smoking but not active smoker | 34 (28) |
| No tobacco smoking history | 79 (66) |
| ECOG performance status | |
| 0–1 | 108 (90) |
| 2–3 | 12 (10) |
| Sarcoma presentation characteristics | |
| Tumor location | |
| Upper extremity | 20 (17) |
| Lower extremity | 78 (65) |
| Trunk | 22 (18) |
| Non-oncologic surgery prior to enrollment† | |
| No | 59 (58) |
| Yes | 51 (43) |
| Maximum Tumor Dimension, cm | |
| Median | 7·6 |
| IQR | 4·5–12·8 |
| Grade | |
| Low | 9 (8) |
| Intermediate | 27 (23) |
| High | 61 (51) |
| Unknown/ungradeable‡ | 23 (19) |
| Histopathology | |
| UPS | 26 (22) |
| Myxoid liposarcoma | 17 (14) |
| Liposarcoma (non-myxoid) | 15 (13) |
| Myxofibrosarcoma | 15 (13) |
| Unclassified | 9 (8) |
| Synovial | 7 (6) |
| Leiomyosarcoma | 6 (5) |
| Fibrosarcomatous transformation of dermatofibrosarcoma protuberans | 4 (3) |
| MPNST | 3 (3) |
| Epithelioid sarcoma | 2(2) |
| Extraskeletal myxoid chondrosarcoma | 2(2) |
| Extraskeletal osteosarcoma | 2(2) |
| Acral myxoinflammatory fibroblastic sarcoma | 2(2) |
| Low grade fibromyxoid sarcoma | 2(2) |
| Other* | 8(7) |
| Presentation | |
| Primary | 108 (90) |
| Recurrent | 12 (10) |
| Treatment characteristics | |
| RT modality/technique | |
| IMRT/VMAT | 57 (48) |
| 3DCRT | 55 (48) |
| Electrons | 5 (4) |
| Protons | 3(3) |
| Interval between RT end date and surgery, weeks | |
| Median | 5·7 |
| IQR | 4·6–6·4 |
| Final Surgical Resection Margin | |
| Positive/uncertain | 12 (10) |
| Negative | 108 (90) |
| Plastics/Reconstructive Surgical specialist participated in wound closure at time of resection | |
| Yes | 95 (79) |
| No | 25 (31) |
| Chemotherapy | |
| Neoadjuvant | 36 (30) |
| Adjuvant | 3 (3) |
| None | 81 (68) |
Abbreviations: IQR, interquartile range; UPS, unclassified pleomorphic sarcoma; MPNST, malignant peripheral nerve sheath tumor; RT, radiation therapy; Neo/Adj, neoadjuvant or adjuvant;
Defined as wide local excision with positive margins (5 patients) or excisional biopsy/unplanned excision (46 patients).
Some sarcomas are, by definition, not gradable.
Other histologies include angiosarcoma, pleomorphic rhabdomyosarcoma, sclerosing epithelioid fibrosarcoma, solitary fibrous tumor, histiocytic sarcoma, dermatofibrosarcoma protuberans (without fibrosarcomatous change) round cell sarcoma-not otherwise specified, and hemangiopericytoma. One patient’s final diagnosis was revised to melanoma upon pathological review of his complete resection specimen.