Table 3.
Univariable analyses of development of major wound complication by patient, tumor, and treatment characteristics
| Variable | No. | MWC at 120 days* (Kaplan Meier curve,%) | p value |
|---|---|---|---|
| Patient characteristics | |||
| Age, years | |||
| ≤60 | 61 | 38 | 0.41 |
| > 60 | 59 | 35 | |
| Sex | |||
| Female | 50 | 26 | 0.30 |
| Male | 70 | 35 | |
| BMI, kg/m2 | |||
| < 30 | 64 | 30 | 0.77 |
| ≥30 | 56 | 32 | |
| Diabetes mellitus | |||
| No | 105 | 28 | 0.010 |
| Yes | 15 | 57 | |
| Smoking history (current or previous) | |||
| No | 79 | 31 | 0.64 |
| Yes | 41 | 32 | |
| ECOG performance status | |||
| 0–1 | 113 | 31 | 0.83 |
| 2–3 | 7 | 31 | |
| Sarcoma presentation characteristics | |||
| Tumor Location | |||
| Upper extremity | 20 | 5 | 0.029 |
| Lower extremity | 78 | 35 | |
| Trunk | 22 | 41 | |
| Non-oncologic excision prior to enrollment | |||
| No | 69 | 31 | 0.74 |
| Yes | 51 | 32 | |
| Maximum Tumor Dimension, cm | |||
| ≤10 | 80 | 28 | 0.26 |
| > 10 | 40 | 38 | |
| Presentation | |||
| Primary | 108 | 32 | 0.61 |
| Recurrent | 12 | 25 | |
| Treatment characteristics | |||
| RT modality/technique | |||
| IMRT/VMAT | 57 | 30 | 0.12 |
| 3DCRT | 55 | 31 | |
| Electrons | 5 | 20 | |
| Protons | 3 | 67 | |
| Interval between RT end date and surgery | |||
| ≤ 8 weeks | 113 | 32 | 0.36 |
| > 8 weeks | 7 | 14 | |
| Final Surgical Resection Margin | |||
| Positive/Uncertain | 12 | 43 | 0.24 |
| Negative | 108 | 30 | |
| Plastics/Reconstructive Surgical specialist participated in wound closure at time of resection | |||
| Yes | 95 | 32 | 0.75 |
| No | 25 | 29 | |
| Chemotherapy | |||
| No | 81 | 30 | 0.71 |
| Yes | 39 | 34 |
Abbreviations: MWC, major wound complication; BMI, body mass index; IMRT/VMAT, intensity modulated radiation therapy/volumetric modulated arc therapy; 3DCRT, 3D conformal radiation therapy.
*
Kaplan Meier curves with log-rank test for difference between curves.