TABLE 3.
Competition between wild-type Ib and truncated Ib variants as determined by Vero cytotoxicity
| Truncated Ib variant | Truncated Ib variant/Ib molar ratio yielding 50% protectiona |
|---|---|
| Ib 28-665 | 125:1 |
| Ib 107-665 | 125:1 |
| Ib 224-665 | 1,028:1 |
| Ib 358-665 | 1,028:1 |
| Ib 466-665 | 1,028:1 |
| Ib 558-665 | >2,056:1 |
| Ib 1-66 | >2,056:1 |
| Ib 1-323 | >2,056:1 |
| Ib 1-466 | >2,056:1 |
| Ib 1-631 | >2,056:1 |
| Ib 1-655 | >2,056:1 |
a
Wild-type Ib (2 nM) and a serial dilution of each truncated Ib variant were added to Vero cells with Ia (2 nM). Results represent the molar ratio of truncated Ib variant to wild-type Ib that afforded 50% protection against iota cytotoxicity.