Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Dec 25;15(1):128. doi: 10.3390/cancers15010128

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of PNA combinations on apoptosis induction. (A,D) Effects of combinations of anti-miRNA PNAs on apoptosis induction in HT-29 (A) and LoVo (D) cells treated for 72 h with a 4 µM concentration of each PNA, as determined using Annexin V assay. Singularly administrated PNA (light gray boxes), combinations of two PNAs (dark gray boxes), triple-PNA combination (black box). The apoptotic profile was determined using Annexin V assay. (B,E) Effects of anti-miRNA PNA combinations on apoptosis induction in HT-29 (B) or LoVo (E) cells treated for 72 h with a 4 µM concentration of each PNA, as determined using Caspase 3/7 assay. Singularly administrated PNA (light gray boxes), combinations of two PNAs (dark gray boxes), triple-PNA combination (black box). (C,F) Representative plots obtained by Annexin V (upper line) and Caspase 3/7 (lower line) assays in HT-29 (C) or LoVo (F) cells. (* p < 0.05, ** p < 0.01, double-PNA treatment was compared with singularly administrated PNA, while triple-PNA treatment was compared with double-PNA combinations. n = 3 independent experiments).