Table 2.
MMR proteins and their functions.
| Bacterial MMR System | Yeast MMR System | Human MMR System | Functions |
|---|---|---|---|
| MutS | MutSα
(MSH2/MSH6) MutSβ (MSH2/MSH3) |
MutSα (MSH2/MSH6) MutSβ (MSH2/MSH3) |
Mismatch recognition |
| MUTL | MutLα (MLH1/PMS1) MutLβ (MLH1/MLH2) MutLγ (MLH1/MLH3) |
MutLα
(MLH1/PMS2) MutLβ (MLH1/PMS1) MutLγ (MLH1/MLH3) |
Match making |
| MutH | PCNA | PCNA | Strand incision |
| RFC | RFC | ||
| MutLα
(MLH1/PMS1) MutLγ (MLH1/MLH3) |
MutLα
(MLH1/PMS2) MutLγ (MLH1/MLH3) |
||
| RecJ | EXO1 | EXO1 | Strand excision (exonuclease) |
| ExoI | |||
| ExoVII | |||
| ExoX | |||
| UvrD | - | - | Strand excision (helicase) |
| DNA polymerase III |
DNA polymerase δ | DNA polymerase δ | Repair synthesis |