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. 2022 Dec 20;15(1):3. doi: 10.3390/cancers15010003

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of inhibition of PCSK9 on mitochondrial respiration and metabolic pathways. (A) OCR was evaluated by the Seahorse assay in Huh7 cells, which were incubated in different media settings, as indicated. NT: non-treated. * Ordinary one-way ANOVA test. (B) Glucose and glutamine consumption as well as lactate and glutamate production by Huh7 cells treated with R-IMMP (10 μM) vs. DMSO (D10) were measured at different time intervals. * Two-way ANOVA test. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001. (C) Viability and cytotoxicity were measured by ApotoxGlo™ Assay in Huh7 cells treated with different doses of R-IMPP for 48 h (n = 1).