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Schematic representation of margetuximab. Margetuximab is a chimeric IgG1 kappa mAb with an optimized Fc region to enhance binding. The Fab and the Fc regions of IgG1 are indicated using brackets. Heavy chain domains are represented by CH1 to CH3, whereas light chain domains are denoted by CL. VH and VL represent the variable heavy chain and variable light chain, respectively.
