1-EBIO	1-ethylbenzimidazolinone
5-FU	5-fluorouracil
Å	Angstrom (unit of length equal to 1 × 10−10 m)
aa	amino acid
Akt	known as protein kinase B or PKB
AP1	activator protein 1
AR	androgen receptor
ASIC	acid-sensing channels
AMLC	acute myeloid leukemia cells
ANO8	Anoctamin 8
ATPase	adenosine triphosphatase
BCL2	B-cell lymphoma 2
BCLxL	B-cell lymphoma-extra large
BID	BH3 Interacting Domain Death Agonist
Bim	BCL2-interacting mediator of cell death
BK	large conductance, Ca2+-activated potassium channels
Ca2+	calcium ion
CAD	Ca2+ release-activated Ca2+ activating domain
CAI	carboxyamidotriazole
CaM	calmodulin
CaMBD	calmodulin-binding domain
CaMK	calmodulin kinase
CaMMUT	calmodulin mutant
cAMP	cyclic adenosine monophosphate
Cav1	Caveolin-1
CC	coiled-coil
CDK2/4/6	cyclin-dependent kinase
cEF	canonical EF hand
CK2	casein kinase 2
CLL	chronic lymphocyte leukemia
CN	calcineurin
COSMIC	catalogue of somatic mutations in cancer
COX-2	cyclooxygenase-2
CRAC	Ca2+ Release-Activated Ca2+
CREB	cAMP-responsive element binding protein
CRISPR/Cas9	clustered regularly interspaced short palindromic repeats/Cas
cryo-EM	cryogenic electron microscopy
DAG	diacylglycerol
DES	Diethylstilbestrol
DKO	double knock-out
dOrai	Drosophila melanogaster Orai
EB	end-binding domain
ECM	extracellular matrix
EGF	epidermal growth factor
EGFR	epidermal growth factor receptor
EGTA	ethylene glycol tetraacetic acid
EMT	epithelial–mesenchymal transition
ER	endoplasmic Reticulum
ERα	estrogen receptor-α
ERK	extracellular signal-regulated kinase
E-Syts	extended-synaptotagmins
ETON	extended transmembrane Orai1 N-terminal
FAK	focal adhesion kinase
FRET	fluorescence resonance energy transfer
GBM	glioblastoma multiforme cells
GoF	gain of function
GPCR	G-protein coupled receptor
GRAMD2A	GRAM Domain Containing 2A
GSK	GlaxoSmithKline compounds
GTPase	guanosine triphosphatase
HBL	human diffuse large B-cell lymphoma
hEag1	human ether a-gogo potassium channel 1
HEK	human embryonic kidney
HeLa	Henrietta Lacks
HIF-1	hypoxia-inducible factor
hOrai1	human Orai1
Huh-7	human hepatoma cell line
ID	inactivation domain
IK	intermediate Ca2+ activated K+ channels
IP3	inositol-triphosphate
IP3R	inositol-triphosphate receptor
K+	potassium ion
KCa	Ca2+ activated K+ channels
KV	voltage-gated potassium channels
Kir	inward-rectifier potassium channels
KRAS	RAS/ERK pathway
La3+	lanthanum ion
LGC	ligand-gated calcium channels
LNCaP	lymph node carcinoma of the prostate
LoF	loss of function
MACC-1	metastasis-associated in colon cancer-1
MAPK	mitogen-activated protein kinases
MßCD	methyl-beta-cyclodextrin
MCF-7	Michigan Cancer Foundation-7
MET	mesenchymal-epithelial transition
miRNA	microRNA
MLCK	myosin light chain kinase
MMPs	matrix metalloproteins
nEF	non-canonical EF-hand domain
NFAT	nuclear factor of activated T cells
NFkB	nuclear factor k-light-chain-enhancer of activated B cells
NMR	nuclear magnetic resonance
NSCLC	chronic lymphocyte leukemia
OASF	Orai—activating small fragment
Orai 1–3	Orai proteins (also as O1–3)
PAT	protein acyl transferase
PBD	polybasic domain
PGE2	prostaglandin E2
PI3K	phosphoinositide 3-kinases
PI4P	phosphatidylinositol 4-phosphate
PIP2	phosphatidylinositol 4,5-bisphosphate
PIP3	phosphatidylinositol-3,4,5-trisphosphat
PKA	protein kinase A
PKC	protein kinase C
PLCε	phospholipase C
PM	plasma membrane
PMCA	plasma membrane Ca2+ ATPase
PYK2	proline-rich tyrosine kinase 2
Rac1	Ras-related C3 botulinum toxin substrate 1
Raf	serine/threonine kinase
Ras	rat sarcoma virus
RASSF4	Ras Association Domain Family Member 4
Ref	references
RNA	ribonucleic acid
ROC	receptor-operated channels
ROS	reactive oxygen species
RTK	growth factor receptor tyrosine kinase
SAM	sterile α-motif
SARAF	store-operated calcium entry-associated regulatory factor
SCID	severe combined immune deficiency
SERCA	sarcoplasmic/endoplasmic reticulum calcium ATPase
SICE	store-independent calcium entry
SigmaR1	Sigma non-opioid intracellular receptor 1
siRNA	small interfering RNA
SK channels	small-conductance Ca2+-activated K+ channels
SMase	sphingomyelinase
SMOC	second messenger-operated channels
SOAP	STIM—Orai association pocket
SOAR	STIM—Orai activating region
SOC	store operated channel
SOCE	store-operated calcium entry
SPCA2	secretory pathway Ca2+-ATPase
STIM	stromal interaction molecule
STIMATE	STIM Activating Enhancer
TM	transmembrane helices
TRAM-34	triarylmethane-34
TRP	transient receptor potential ion channel (C-canonical, M-melastatin, V-vallinoid)
VGCC	voltage-gated calcium channels
Wnt	Wingless Int-1