Table 1.
Top 20 Genes Upregulated in the Lungs of IFN-γ Knockout Mice Followed by Wild-type and IL-17 Knockout Mice Identified Using Microarrays
| Gene | IFN-γ KO | WT | IL-17 KO |
|---|---|---|---|
| S100a8 | 37.1 | 16.5 | 4.3 |
| Mmp8 | 19.7 | 10.8 | 7.3 |
| S100a9 | 19.5 | 11.5 | 4.2 |
| Retnlg | 19.1 | 12.0 | 5.9 |
| Slc26a4 | 18.5 | 18.3 | 11.7 |
| Cxcl5 | 10.6 | 7.5 | 5.8 |
| Lcn2 | 8.8 | 8.7 | 6.4 |
| Ccr1 | 6.3 | 5.2 | 2.0 |
| Gzma | 6.2 | 2.2 | 2.1 |
| Il1b | 6.0 | 3.1 | 1.3 |
| Il1r2 | 5.7 | 4.6 | 3.9 |
| Cxcr2 | 5.4 | 4.0 | 2.2 |
| Cd177 | 5.0 | 4.8 | 3.3 |
| Ccl12 | 4.7 | 4.5 | 1.2 |
| Mmp3 | 4.4 | 1.3 | 1.1 |
| Mmp9 | 4.2 | 2.2 | 1.0 |
| Ifitm6 | 4.1 | 3.8 | 1.8 |
| Nfil3 | 3.8 | 3.0 | 2.2 |
| Arg1 | 3.8 | 1.5 | 1.2 |
| Arg2 | 3.8 | 2.4 | 1.6 |
Definition of abbreviations: SEB = staphylococcal enterotoxin B; WT = wild-type.
Table shows fold-increase in gene expression at 4 hours in SEB-challenged mice compared to respective naïve mice in each genotype.