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. 2022 Dec 26;15(1):138. doi: 10.3390/cancers15010138

Table 1.

Immune response elicited by PTM-modified TAA.

PTMs TAA Type of Tumor in Which TAA Has Been Identified or to Which the Antigen Is Associated Immune Recognition (If Any) References
Acetylation ENO1 Pancreas NA [16]
p53 Colon, Prostrate, Pharynx CD4+ T Cell [19]
Phosphorylation MART-1 Melanoma, Leukemia CD4+ T Cell [29]
IRS2 Melanoma, Breast, Ovary, Colon CD8+ T Cell [18,30,31]
β-Catenin Ovary, Melanoma CD8+ T Cell [30,31]
Breast cancer antiestrogen resistance 3 Melanoma CD8+ T Cell [30]
p53 Head and Neck CD4+ T Cell [21]
ENO1 Pancreas Ab, CD4+ T Cell [14,15]
CDC25b Melanoma, Breast, Ovary, Colon, Leukemia CD8+ T Cell [18,31]
TNF receptor associated protein (TRAP-1) Lung CD8+ T Cell [32]
Vim Colon CD4+ T cells [33]
Citrullination Vim Melanoma, Lung CD4+ T Cell [17,34,35,36]
Enolase Melanoma, Lung CD4+ T Cell [17,35,36,37]
Glycosylation MUC1 Breast, Ovary CD8+ T Cell,
Ab
[38,39]
Sialylation Silayl-Tn-Antigen Breast, Ovary Ab (IgM) [40,41,42,43]
SUMOylation p53 Sarcoma NA [44]
Methylation Enolase Pancreas NA [16]