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. 2022 Dec 26;15(1):143. doi: 10.3390/cancers15010143

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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c-KIT and its downstream signaling are inhibited by 6r, 6s, and 7c in (A,B) GIST-T1, (C,D) HMC1.2, and (E,F) c-KIT D816V Ba/F3 cells. Quantification of phosphorylated c-KIT and STAT3 levels by the treatment of 6r, 6s, and 7c in GIST-T1, HMC1.2, and c-KIT D816V Ba/F3 cells. (average ± S.D., n = 3 one-way ANOVA; * p < 0.05).