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. 2022 Dec 26;15(1):143. doi: 10.3390/cancers15010143

Figure 5.

Figure 5

Effects of 6r, 6s, 7c, and imatinib on induction of apoptosis and cell cycle arrest in (A–D) GIST-T1 (0.05 μM), (E–H) HMC1.2 (1 μM), and (I–L) c-KIT D816V Ba/F3 (1 μM) cells. Cells were stainedAnnexinV-FITC and PI. Flow cytometry analysis was assessed to determine the percentage of apoptotic cell. Treatment (24 h) with 6r, 6s, 7c, and imatinib induced G0/G1 arrest in GIST-T1 (0.01 μM), HMC1.2 (0.5 μM), and c-KIT D816V (0.5 μM) Ba/F3 cells. (M) Treatment (24 and 48 h) with 6r, 6s, 7c, and imatinib induced PARP cleavage in HMC1.2 cells. (average ± S.D., n = 3 one-way ANOVA and Tukey’s multiple comparisons test; * p < 0.05. ns: not significant).