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Enzymatic inhibitory activities of thiazolo[5,4-b]pyridine derivatives 6r, 6s, and 7c against c-KIT V560G/D816V.
| Entry | IC50 (μM) a |
|---|---|
| c-KIT V560G/D816V | |
| imatinib | 37.93 ± 8.68 |
| sunitinib | 3.98 ± 1.18 |
| 6r | 4.77 ± 0.38 |
| 6s | 7.67 ± 2.64 |
| 7c | 5.07 ± 0.71 |
a ADP-Glo kinase assay.
