Table 4.

Anti-proliferative activities of thiazolo[5,4-b]pyridine derivatives 6r, 6s, and 7c against c-KIT D816V Ba/F3 cells and parental Ba/F3 cells.

Entry	Ba/F3 cells GI50 (μM) a
	c-KIT D816V	Parental
imatinib	12.25 ± 2.06	17.00 ± 0.20
sunitinib	0.58 ± 0.29	2.72 ± 0.30
6r	1.11 ± 0.47	8.06 ± 0.57
6s	1.06 ± 0.15	10.54 ± 3.59
7c	0.53 ± 0.06	10.52 ± 3.44

^a GI₅₀ means the concentration at which a compound causes half-maximal growth inhibition.