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. 2022 Dec 22;15(1):52. doi: 10.3390/cancers15010052

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Galectin-3 expression in normal colonic mucosa: a progressive increase in Gal-3 expression occurs from the basal to the apical side of the crypt; within the nucleus, Gal-3 is localized in the dense fibrillar components of the nucleolus as well as in the periphery of the fibrillar centers.(B) Changes in Gal-3 expression and/or subcellular localization during colorectal cancer progression: Gal-3 expression is increased in advanced cancer. A different subcellular localization (from the nucleus to the cytoplasm) is observed during progression from colorectal adenoma to carcinoma.

(A) Galectin-3 expression in normal colonic mucosa: a progressive increase in Gal-3 expression occurs from the basal to the apical side of the crypt; within the nucleus, Gal-3 is localized in the dense fibrillar components of the nucleolus as well as in the periphery of the fibrillar centers.(B) Changes in Gal-3 expression and/or subcellular localization during colorectal cancer progression: Gal-3 expression is increased in advanced cancer. A different subcellular localization (from the nucleus to the cytoplasm) is observed during progression from colorectal adenoma to carcinoma.